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Metastasis is one of the most important factors in the prognosis and choice of treatment strategyof patients with head and neck squamous cell carcinoma (HNSCC). In order for disseminationto take effect, tumor cells must segregate themselves from their primary tumor site andmigrate into the blood or lymphatic vessels. To detach from the primary tumor, cells have todisrupt cell-cell adhesion, remodel of the cytoskeleton, change in cell-matrix adhesion and finallyreturn to their original condition. This temporary and reversible process is known as theepithelial-mesenchymal transition (EMT). EMT is a dynamic cellular process in which epithelialcells acquire mesenchymal features and suggested to play an important role during cancerinvasion and metastasis. With the recent explosion of knowledge on EMT in carcinogenesis,EMT has become an interesting target for anticancer therapy. This review article first highlightsat the biochemical changes that take place around the cell membrane called cadherinswitching during EMT and looks at the current literature on EMT in HNSCC. Understandingthe mechanism of EMT will provide insight to the metastasis of HNSCC and may lead to thedevelopment of novel anti-cancer therapeutics.