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Anterior interosseous nerve is a motor branch from median nerve. It innervates three muscles, the flexor pollicis longus, the flexor digitorum profundus, and the pronator quadratus muscles in the forearm. Anterior interosseous nerve syndrome refers to a neuropathy affecting this nerve, to develop weakness of innervated muscles. The etiology can be diverse and the pathophysiology is not clearly documented. We report a case of a 67-year-old male patient with diabetes, who presented symptoms of right thumb and index finger weakness, forearm pain, which was in conclusion diagnosed as anterior interosseous nerve syndrome through electrodiagnostic studies. His anterior interosseous nerve syndrome was revealed as due to fluid extravasation. Fluid extravasation can cause various side effects, and peripheral nerve injury is an uncommon side effect. This is a rare case of anterior interosseous nerve syndrome developed from fluid extravasation.