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The purpose of this paper is to comprehensively examine the significance and limitations of the structural perspective study on lexical semantic relations, and to explore ways to view the expansion of semantic relations from an integrated perspective. The flow of research on semantic relations from the structuralist point of view was focused on examining how the perspective of ‘opposition’ has changed. In addition, through the contrast between structuralism and contextualism, we examined how the opposing perspectives of structure/context, langue/parole, and concept/use led to differences in looking at lexical semantic relations. Language is not perfectly systematic, but it is not totally disordered, and establishing a present system in the process of order and disorder cycles is the essential goal of lexical semantic research. To this end, concepts and usage can play a complementary role. In discussing the change and direction of the structuralism, there is a need to look at the semantic relations in an integrated manner and to capture aspects of the formation of new semantic relations. The semantic relations that have been discussed separately as ‘synonymy, antonymy, hyponymy’ are only partially shown to specify the whole lexical semantic system. It needs to be systematically integrated.