초록 close

An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other organs has been conducted on this matter yet. So, an in-depth discussion on toxicological techniques is needed to determine whether or not PHMG is toxic to organs other than just the lungs. For the test of target organ toxic¬ity by PHMG exposure, a toxicokinetic study must first be conducted. However, mea¬surement method for PHMG injected into the body has not yet been established be¬cause it is not easy to analyze polymer PHMG, so related base studies on analytical technique for PHMG including radio-labeling chemistry must come first. Moreover, re¬search on exposure-biomarker and effect-biomarker must also be conducted, primarily related to clinical application. Several limitations seem to be expected to apply the bio¬marker study to the patient because much time has passed after exposure to the hu¬midifier disinfectant. It is why a more comprehensive toxicological researches must be introduced to the causality for the victims.