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Objectives: A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both domestic and international references, examined the chemical management system, working environment, level of exposure, and possible associated risks. This information may be utilized in the future to deter¬mine appropriate exposure levels in working environments. Methods: Hazard assessment was performed using chemical hazard information ob¬tained from international agencies, such as Organization for Economic Cooperation and Development-generated Screening Information Data Set and International Program on Chemical Safety. Information was obtained from surveys conducted by the Minister of Employment and Labor (“Survey on the work environment”) and by the Ministry of En¬vironment (“Survey on the circulation amount of chemicals”). Risk was determined ac¬cording to exposure in workplaces and chemical hazard. Results: In 229 workplaces over the country, 831 tons of DEHP have been used as plasti¬cizers, insecticides, and ink solvent. Calculated 50% lethal dose values ranged from 14.2 to 50 g/kg, as determined via acute toxicity testing in rodents. Chronic carcinogenicity tests revealed cases of lung and liver degeneration, shrinkage of the testes, and liver cancer. The no-observed-adverse-effect level and the lowest-observed-adverse-effect level were determined to be 28.9 g/kg and 146.6 g/kg, respectively. The working environment assessment revealed the maximum exposure level to be 0.990 mg/m3, as compared to the threshold exposure level of 5 mg/m3. The relative risk of chronic toxicity and repro¬ductive toxicity were 0.264 and 0.330, respectively, while the risk of carcinogenicity was 1.3, which is higher than the accepted safety value of one. Conclusions: DEHP was identified as a carcinogen, and may be dangerous even at con¬centrations lower than the occupational exposure limit. Therefore, we suggest manage¬ment of working environments, with exposure levels below 5 mg/m3 and all workers uti¬lizing local exhaust ventilation and respiratory protection when handling DEHP.