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Botulinum toxins (BoTXs) are potent inhibitors of neurotransmission mediated by exocytosis, cleaving synaptosomalassociatedprotein of 25 kDa (SNAP-25) to cause paralysis and death in human. Among them, botulinum toxin typeA (BoTX/A) is both clinically and cosmetically important because of its wide application in clinical and cosmetic treatment. Therefore, development of feasible and effective model-base assay system might be very helpful to understand the effect ofthe toxin. In this study, we have examined the physiological effect of BoTX/A on Caenorhabditis elegans, a free-living soilnematode model system. Worms treated with BoTX/A showed defective egg-laying, yolk protein consumption, andlocomotion while they were normal in developmental process. Worms’ susceptibility to BoTX/A suggests potential utilityfor the assay of BoTX/A.