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The aim of this study was to assess oral health related quality of life and evaluation the risk factors in menopausal woman. The subjects of this study were 531 menopausal woman from August 5 to September 27, 2012. Data were analyzed with t-test, one-way ANOVA, and binary logistic regression analysis SPSS 12.0. The most influential factors of perceived oral symptoms was menopause symptoms (odds ratio [OR], 3.72; 95% confidence interval [CI], 2.34∼5.92), anxiety symptoms (OR, 2.14; 95% CI, 1.34∼3.41), drinking (OR, 1.37; 95% CI, 1.04∼1.81), living with a spouse (OR, 0.83; 95% CI, 0.70∼0.98). There are a statistically significant relationship between perceived oral symptoms and menopause, anxiety symptoms. The postmenopausal woman can be the important menopause and anxiety symptoms interventions in maintaining perceived oral health as good.