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Purpose: The purpose of this study was to identify levels of perceived stigma, self-esteem, quality of life and factors influencing on quality of life in people with Hansens' disease. Methods: The subjects were 128 people in Sorokdo National Hospital, two nursing homes, and three settlements. The stigma scale, self-esteem scale, and World Health Organization's quality of life instrument were used. Data were collected through self-reported questionnaires from July to August, 2010 and analyzed by t-test, ANOVA, Ducan's multiple range test, Pearson's correlation coefficients, and stepwise multiple regression by SAS. Results: The level of perceived stigma was 3.93, self-esteem was 26.2, quality of life was 2.78. Self-esteem was positively associated with quality of life. Through the multiple regression, it was found that self-esteem and job were factors influencing of quality of life with 43% of predictability. Conclusion: It was found that self-esteem and job were important for people with Hansen's disease. To improve the quality of life in people with Hansen's disease, it is necessary to develop nursing interventions fostering self-esteem and decreasing perceived stigma.