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Objectives :The purpose of this study is to evaluate the effects of Daeyeongjeongami-bang on menopausal disorder patients. Methods :We recruited 3 menopausal disorder patients who have been suffering from hot flush, fatigue and depression. In addition, the patients had been administrated Daeyeongjeongami-bang. The patients of menopausal disorder had been estimated with Kupperman's index, Menopause rating scale, Beck's depression Inventory, Self rating depression scale,Visual analogue scale and Heart rate variability. We measured Kupperman's index, Menopause rating scale, Beck's depression inventory and Self rating depression scale for every seven days. Heart rate variability was estimated twice,before and after the treatment. Results :After the treatments, symptoms of menopausal disorder were decreased. Conclusions :This study suggests that Daeyeongjeongami-bang is significantly effective on menopausal disorder patients with hot flush, fatigue and depression.