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Oxidized hairdyes which are frequently used in dyeing cause abnormal scalp and contact dermatitis. And they even do hair loss in severe cases. Pleuropterus multflorus extract cream was used to relieve damaged scalp due to frequent use of oxidized hairdyes. First, the result which carried out the cytotoxicity test (mtt-assay) to check the safety of Pleuropterus multflorus extract has found that there is no cytotoxicity on concentration of less than 100 μg/mL. The result which observed the effect by applying polygonum multiflorum extract cream which was made based on them three times per week to the SD-rat back part that caused scalp damage as the oxidized hairdye is as follow: We applied Pleuropterus multflorus cream to SD-rat whose scalp was damaged by oxidized hairdye. In contrary to control group, erythema and edema appeared in first 2~4 weeks which completely alleviated in week 6~8. We also conducted a patch test on 20people to investigate allergic reaction of Pleuropterus multflorus cream. As a result, P.I.I was 0.072, which is equivalent to non-irritation reaction, thus proving rare existence of skin irritation. Therefore, the study confirmed safety of Pleuropterus multflorus cream and alleviation effect on scalp damage through basic level test.