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Polyphenol contents and antiradical scavenging activities of nanopowdered peanut sprout (NPPS) and powdered peanut sprout (PPS) were compared using various antiradical scavenging assays such as α-diphenyl-β-picryl-hydrazyl free radical (DPPH•)scavenging, 2, 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)radical scavenging activity, reducing power, and superoxide dismutase. The size of NPPS ranged from 300–350 nm as observed by the particle size analyzer, much smaller than that of PPS ranging from 50 to 150 μm. Total polyphenol contents in NPPS (455.05±18.69 μg/mL) were relatively higher than those of PPS (421.99±14.94 mg/mL). NPPS showed higher antioxidant activity than PPS at all concentrations (2.5, 5, 10, 15 and 20 mg/mL). Overall, the antiradical scavenging activity was much higher in NPPS and nanogrinding increases the surface area of polyphenol with higher functional site.