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목 적:소아청소년을 대상으로 2010-2011 인플루엔자 백신의 야외 효능을 확인하고자 하였다. 방 법: 2010년 9월에서 2011년 2월까지 소아 청소년을 대상으로 서울 경기지역의 7개 병원과 1개 초등학교에서 인플루엔자 백신을 접종한 시험군과 접종하지 않은대조군을 모집하였다. 급성 발열성 호흡기 질환 증상이있을시 임상시험기관에 방문하도록 하여 검체를 채취하여 감염여부를 확인하였다. 결 과:시험 군 407명 중 3명(0.74%)에서 3건의 신종H1N1 인플루엔자 바이러스가 검출되었고, 대조군 230명중 10명(4.35%)에서 12건을 검출하여 9명(3.91%)에서9건의 신종 H1N1, 3명(1.30%)에서 3건의 H3N2 인플루엔자 바이러스를 검출하였다. 시험군에서의 인플루엔자발생률은 0.74%, 대조군에서 4.35%였다. 백신의 야외효능은 83.2%였다. 결 론:소아청소년을 대상으로 2010-2011년 인플루엔자 백신의 야외효능은 우수하였음을 확인하였다.


Purpose :We conducted a prospective comparative clinical study to determine the field efficacy of the 2010–2011 influenza vaccines [Influenza virus strains; A/California/7/2009 (H1N1), A/Perth/16/2009 (H3N2), B/Brisbane/60/2008] in healthy Korean children under 18 years of age. Methods : In this study, we enrolled subjects aged between 6 months and 18 years and divided them into 2 study groups:a group who received the influenza vaccines (407 subjects), and a control group who did not receive the influenza vaccines (230 subjects). Ours was a multicenter study that involved 7 hospitals, including the Korea Cancer Center Hospital. The study was conducted between September 2010 and February 2011. We collected nasal wash or throat swab samples from subjects who presented with acute febrile respiratory or influenza-like illnesses at the hospital. We used PCR to confirm the presence of the influenza virus in the respiratory samples and characterize the virus type. Results : In this study, we collected 22 respiratory samples from the influenza-vaccinated group and found 3 cases of influenza virus infection. Similarly, we collected 21 samples from the control group and found 12 cases of influenza virus infection among 10 subjects during the study period. We determined the field efficacy of the 2010-2011 seasonal influenza vaccines to be 83.2% in healthy Korean children and adolescents. Conclusion : In this study, we determined the field efficacy of the 2010–2011 seasonal influenza vaccines in healthy Korean children and adolescents. We found that the field efficacy of 2010–2011 seasonal influenza vaccines was adequate.