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Purpose: Asthma is prevalent in many countries. Few studies have investigated the association between asthma and concomitant diseases. Weretrospectively analyzed the fourth Korean National Health and Nutrition Survey database, performed in 2008 using nationwide stratified randomsampling to obtain a representative cohort of the Korean population. Methods: We evaluated the association between both self-reported everasthmaticsand wheezers and concomitant diseases such as arthritis, hypertension, gastrointestinal (GI) ulcers, dyslipidemia, diabetes mellitus, rhinitis,depression, stroke, and obesity in subjects aged ≥40 years. A multivariate analysis was performed to identify concomitant diseases independentlyassociated with asthma, after adjustment for age, gender, income, cigarette smoking, and other chronic diseases. Results: Of the total of4,445 subjects, 2,596 (58.4%) were female and the mean age was 58.3 years. Of the 4,445 subjects, 195 (4.4%) had been diagnosed with asthma atsome point, and 444 (10%) were wheezers. Multivariate analysis showed that arthritis (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.26-2.42),rhinitis (OR 1.78, 95% CI 1.14-2.78), depression (OR 1.45, 95% CI 1.05-2.07), and obesity (OR 1.61, 95% CI 1.08-2.40) were significantly associatedwith self-reported ever-asthma, and arthritis (OR 1.50, 95% CI 1.19-1.909), hypertension (OR 1.34, 95% CI 1.07-1.67), GI ulcers (OR 1.48, 95% CI1.05-2.08), rhinitis (OR 1.60, 95% CI 1.16-2.19), depression (OR 1.94, 95% CI 1.51-2.48), and obesity (OR 1.56, 95% CI 1.17-2.09) were significantlyassociated with wheezers. Conclusions: These findings indicate that arthritis, rhinitis, depression, and obesity may be associated with both selfreportedever asthma and wheezers in the Korean population.