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Food allergy has increased dramatically in prevalence over the past decade in westernized countries, and is now a major public health problem. Unfortunatelyfor patients with food allergy, there is no effective therapy beyond food allergen avoidance, and rapid medical treatment for accidentalexposures. Recently, oral immunotherapy (OIT) has been investigated as a treatment for this problem. In this review, we will discuss the progress indeveloping OIT for food allergy, including a novel approach utilizing Xolair (anti-IgE monoclonal antibody, omalizumab) in combination with OIT. Thiscombination may enhance both the safety and efficacy of oral immunotherapy, and could lead to a widely available and safe therapy for food allergy.