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The paper deals with three main topics: a) the definition of System Thermal-Hydraulics (SYS TH), b) a historical outline for SYS TH and, c) the description of elements for reflection when planning research projects or improvement activities, this last topic being the main reason for the paper. Distinctions between basic thermal-hydraulics and computational Fluid-Dynamics (CFD) on the one side and SYS TH on the other side are considered under the first topic; stakeholders in the technology are identified. The proposal of Interim Acceptance Criteria for Emergency Core Cooling Systems in 1971 by US NRC (AEC at the time) is recognized as the starting date or the triggering event for SYS TH (second topic). The complex codes and the main experimental programs (list provided in the paper) constitute the pillars for SYS TH. Caution or warning statements are introduced in advance when discussing the third topic: a single person (or a researcher) has little to no possibility,or capability, of streamlining the forthcoming investments or to propose a roadmap for future activities. Nevertheless, the ambitious attempt to foresee developments in this area has been pursued without constraints connected with the availability of funds and with industrial benefits or interests. Demonstrating the acceptability of current SYS TH limitations and training in the application of those codes are mentioned as the main challenges for forthcoming research activities.