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The objective of this study was to prepare isosorbide 5-mononitrate tablets with an extended-release base using paraffin wax. The goal was to develop a tablet formulation equivalent to the commercially available Imdur  Long Acting Tablet 60 mg. We investigated the effect of paraffin wax on the dissolution rate of isosorbide 5-mononitrate and performed an in vitro dissolution test using the paddle method. The paddle stirring rates were varied from 50 to 150 rpm to mimic pre- and postprandial conditions and determine the effect of food uptake affects on drug absorption. In the dissolution study, isosorbide 5-mononitrate tablets with paraffin wax exhibited extended-release behaviors from 72 to 90 % over an 8-h period,of which the #4 formulation (110-mg paraffin wax) was comparable to the Imdur Long Acting Tablet 60 mg. From the f2 factor, the paddle stirring rate did not affect the dissolution both pH 1.2 and 6.8 between the formulation #4and Imdur Long Acting Tablet 60 mg for 10 h. The results suggest that the properties of oral extended-release tablet of isosorbide 5-mononitrate containing paraffin wax were comparable to those of the Imdur Long Acting Tablet 60 mg, and satisfied the guidelines of the Korea Food and Drug Administration.