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Purpose: The purpose of the study was to determine the effects of Simulation-Based Training on anxiety,depression and self-efficacy in nursing students. Methods: A quasi-experimental research design (one group pre-test and post-test design) and a questionnaire for measuring anxiety, depression and self-efficacy were used in this study. The participants were 97 students of a nursing college. Data were collected before the program and immediately after the program. Means, SD,paired t-test, and Cronbach's ⍺ with the SPSS/WIN 12.0 program were used to analyze the data. Results: There was a statistically significant decrease in anxiety (p=.012) and a statistically significant increase in self-efficacy (p=.048), but not in depression (p=.439) among the nursing students who underwent Simulation-Based Training. Conclusion: From the findings of this study, it was demonstrated that Simulation-Based Training interventions had effects on anxiety and self-efficacy. Therefore, future and/or repeat studies will actively apply Simulation-Based Training interventions.