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The stringent effluent water quality requirements force to use the MBR to treat wastewater. Since there is no design parameters available, especially for sludge production, the factors used for conventional activated sludge system are applied to calculate the amount of sludge produced from the MBR system. In this study, the computer simulation was used to define the yield. Four typical Korean domestic wastewater characteristics estimated from both combined and separated sewer systems were used as influent. And A2O-MBR and UCT-MBR configurations with 4 operation modes for each configuration were simulated. It was found that yield was inversely proportional to SRT. However, effluent T-N concentration and T-P removal efficiency are proportional to yield. Also, yield was inversely proportional to effluent T-P concentration. Yield showed strong relation with SRT. The yield in MBR system had a range from 0.34 to 0.43 kgMLVSS/kgBOD with Korean domestic wastewater.