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Objective To investigate the synergic eff ects of mirror therapy and neuromuscular electrical stimulation (NMES)for hand function in stroke patients. Method Sixty patients with hemiparesis after stroke were included (41 males and 19 females, average age 63.3years). Twenty patients had NMES applied and simultaneously underwent mirror therapy. Twenty patients had NMES applied only, and twenty patients underwent mirror therapy only. Each treatment was done fi ve days per week, 30 minutes per day, for three weeks. NMES was applied on the surface of the extensor digitorum communis and extensor pollicis brevis for open-hand motion. Muscle tone, Fugl-Meyer assessment, and power of wrist and hand were evaluated before and after treatment. Results There were significant improvements in the Fugl-Meyer assessment score in the wrist, hand and coordination, as well as power of wrist and hand in all groups after treatment. Th e mirror and NMES group showed significant improvements in the Fugl-Meyer scores of hand, wrist, coordination and power of hand extension compared to the other groups. However, the power of hand fl exion, wrist fl exion, and wrist extension showed no signifi cant diff erences among the three groups. Muscle tone also showed no signifi cant diff erences in the three groups. Conclusion Our results showed that there is a synergic effect of mirror therapy and NMES on hand function. Therefore, a hand rehabilitation strategy combined with NMES and mirror therapy may be more helpful for improving hand function in stroke patients than NMES or mirror therapy only.