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The aim of this study was to investigate the effects of a 12 week Pilates exercise program on body composition, cholesterol, hs-CRP and leptin in male obese adults. Subjects were obese 30-42 year old men (BMI=25.0-30.0kg/m²). They were classified into a Pilates group (N=7) and control group (N=7). Pilates program consisted of upper abdominal curl, spine stretch forward, roll up, rolling, single leg stretch, criss crosses, double straight leg, single straight leg stretch, single and double kick, side up/down kick in parallel and side band, etc. Training was preformed 3 days/week for 65 min during the 12 weeks. Exercise intensity was monitored using heart rate monitor and peak intensity was reached between 50 and 75% HRR. Data was analyzed by repeated two way ANOVA with group and period, and then post Hoc test(a=.05) with paired and independent t-test were performed. After 12 week of Pilates training, waist, hip and chest circumstance in body composition factors were significantly decreased with a main effect of period and an interaction effect of period and group in Pilates group. In lipoprotein factors, total cholesterol had a main effect of period and LDL-C had an interaction effect of period and group. In inflammatory markers, hs-CRP were significantly decreased with a main effect of period and an interaction effect of period in Pilates group. In conclusion, 12 weeks of Pilates training seemed to be effective to improve cardiovascular disease risk factors in obese adults.