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The purpose of this study is to identify effects of participation of amateurs and professionals in mixed martial arts in games on stress hormones and muscle damage and inflammation. The subjects in this study included amateurs (n=7) and professionals (n=7). The methods included measurements of blood pressure and pulse, and their blood was collected at resting one day before the games (the 1st period), 10 minutes before the game (the 2nd period), and 10 minute immediately after the games (the 3rd period). As a result, all the items did not show differences between the amateurs and professionals. However, there was significant difference in periods within the groups: as for HR, the two groups showed significant differences in periods (p<.05); as for SBP, the two groups showed significant differences only in the first and the second period and the first and third period (p<.05); and as for DBP, the two groups showed significant differences only in the first and the second period (p<.05). As for cortisol, epinephrine, norepinephrine, CK, LDH there were significant differences in both groups by periods (p<.05). As for hsCRP, there was no significant difference in both groups, but in the third period that of the professionals was higher than that of the amateurs. In conclusion, stress hormones did not show difference by periods between amateurs and professionals who participated in the mixed martial arts games but the hormones were increased considerably immediately before the games and after the games, a finding that shows both groups were under much stress in participation in the games. Meanwhile, the subjects showed muscular damage after the games.