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In recent decades, drugs have become the standard treatment for major depression while the place for psychotherapyhas been became narrow. However, psychotherapy is widely used in clinical practice for the t reatment of depression.The use of psychotherapy for the treatment of depression rests upon that the symptom picture and psychological state of the patient should be clarified and managed and also that recent studies about psychotherapy for depression have been shown to be efficacious. The reasons for the necessity of psychotherapy for the treatment of depression may be as follows:1) Even though, at the micro level, depression may be the changes in neurotransmitters or functions of various receptors, it may be manifested by the changes in moods, thoughts, behaviors and relations. 2) Despite the evidence for the efficacy of drugs, some depressed patients especially children and adolescents, women in their reproductive years, and elderly persons, cannot or do not want to take them, and psychotherapy offers another alternative. 3) Whatever the etiology of depression, this has consequences in the patient’s social, family, and work functioning and these may not be improved by drug only and these need the other type of intervention beside drug. 4) The psychotherapy of the acute episode of depression will have enduring effects and prevent recurrence and relapse by changes in coping style and adaptive resources. 5) Many researches have shown tha the combined psychological and psychopharmacological treatment is most effective for the treatment of depression. Interpersonal psychotherapy (IPT) is one of the psychotherapy which are useful in clinical practice for the treatment of depression in these purposes. IPT is a specific psychotherapy which requires only limited time and based on the idea that the symptoms of depression are usually associated with something going on in one’s personal life, usually with people to whom one feels close and who are important to one. It began in 1968 by Klerman and colleagues as part of clinical trail of depressed patients for testing it’s effect of relapse prevention following reduction of acute symptoms of depression with pharmacotherapy. And then it has evolved over nearly 40 years of treatment and research experience with ambulatory depressed patients. It has now been modified for many types of depressive disorders and other areas including pati nts with bulimia and drug abuse. In this review, I will try to introduce the concepts, theoretical background, methods and specific techniques, extended applications beyond depression, and treatment efficacy of IPT.