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Ultrasound has been studied for stimulation of bone fracture healing for a long time. After many researches of high and low intensity ultrasound, researchers became focused on low-intensity pulsed ultrasound(LIPUS) recently. One of the effects of LIPUS is acceleration of bone regeneration without unfavorable results such as bone necrosis and fibrous or delayed healing, but the exact mechanism is not elucidated yet. The purpose of this feature article is to review researches of LIPUS up to now and to know the trend and future research focuses.