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Purpose: This work aimed to elucidate the anti-inflammatory effect of pegmatite in vitro and in vivo. Methods: Author evaluated the suppressive effects of pegmatite on lipopolysaccharide(LPS)-stimulated nitric oxide(NO) production, TNF-α and IL-6 release in the RAW 264.7 murine macrophages. Results: Treatment of RAW 264.7 cells with pegmatite significantly reduced LPS-stimulated NO production and inflammatory cytokine such as TNF-α and IL-6 secretion in a concentration-dependent manner. Also pegmatite showed topical anti-inflammatory activity in the arachidonic acid(AA)-induced ear edema and acetic acid-induced increase in capillary permeability assessment in mice. It was also found that pegmatite(10mg per ear in DW) inhibited arachidonic acid induced edema at 24 h more profoundly than 1h by topical application. Furthermore, the vascular permeability increase induced by acetic acid was significantly reduced in mice that received pegmatite in 50mg per mouse. Received February 3, 2009Revised June 9, 2009Accepted August 26, 2009Address Correspondence: Keun Cheol Lee, M.D., Ph.D., Department of Plastic & Reconstructive Surgery, College of Medicine Dong-A University, 1, 3ga, Dongdaesin-dong, Seo-gu, Busan 602-715, Korea. Tel: 051)240-2968/Fax: 051)243-5416/E-mail: pokdungi@dau.ac.kr Conclusion: Therefore the results of the present study suggest that pegmatite is a potent inhibitor of the LPS- induced NO and inflammatory cytokine in RAW 264.7 macrophages and showed anti-inflammatory activities in vivo animal model.