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In this study, an effective monitoring and the investigation of treatment efficiency of pharmaceuticals from the influent and effluent of livestock wastewater treatment plants (WWTPs) by LC/ESI-MS/MS was performed. Thirteen pharmaceuticals including anntibiotics, growth promoters and disinfectants were assayed from twelve WWTPs in South Korea. The analytical method for pharmaceuticals from wastewater samples gave above 60% of recoveries from the spiked blank samples. The calibration curves showed good linearities (above r2=0.99) in the concentration range of 0.01~10.00 ng/mL. Limits of detection (LOD, at S/N>3) were the range of 0.00128~0.04505 ng/mL, and methods detection limits (MDL, at RSD<20% and S/N>10) were 0.00552~0.15015 ng/mL in surface water. Accuracy and precision from spiked blank samples were -12.4~20.6% and 0.6~24.0% from spiked blank samples, respectively. The established method could be used to determine low concentration levels of pharmaceuticals in environmental samples. From few influents of livestock WWTPs, chlortetracycline and acetaminophen were detected with the highest concentration (70.87 μg/ mL and 1.35 μg/mL, respectively) among the monitoring pharmaceuticals. And also lincomycin, sulfathiazole, sulfamethazine, trimethoprim, acetyl salicylic acid, tylosin, glutaraldehyde and formaldehyde were detected with 0.21~294.02 ng/mL from the influents of WWTPs.