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To investigate the anti-diabetic effects of water-extracted propolis (WEP) in streptozotocin (STZ)-induced diabetic rats, male Sprague-Dawley (SD) rats were induced diabetes mellitus by the STZ injection (45mg/kg b.w.) and were divided into 3 groups and subjected to one of the following treatments. Negative control group received basal diets and two of STZ treated group supplied with 150 or 300mg/kg-WEP (WEP groups) orally for 4 weeks, respectively. Diabetic rats group was showed the lower weight compared to the normal rats. Food diet and drinking water supply in STZ treated group was higher than in normal or WEP groups. The plasma glucose levels of the WEP-treated groups were lower than STZ-control group. In macrophage cell culture, cytokines (TNF-α, IL-1β, IFN-γ) levels in WEP-treated groups was decreased compared with STZ treated group. Spleen cell proliferation by treatment LPS was significantly increased. Immunostaining of insulin containing immune cells at pancreas tissue in WEP-treated group were significantly increased compared with STZ group. These results suggests that WEP may contributes an anti-diabetic action by inhibition of diabetic inducing substances such as IL-1α, TNF-β, IFN-γ or by induction of insulin regulating glucose.