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Purpose: The purpose of this study was to identify the affecting factors on the health promoting behaviors of the clinical nurses. Methods: This study was a trans-sectional survey research. The subjects of this study were 206 clinical nurses. The data were collected by questionnaires and medical records. Results: There were significant positive relationships between health promoting behavior and perceived health status, job satisfaction, familial support. There were significant negative relationships between health promoting behavior and depression. The significant affecting factors on the health promoting behaviors of the clinical nurses were depression, familial support and job satisfaction. These 3 factors explain 18.6% of the health promoting behaviors of the clinical nurses. Conclusion: This study provides the empirical evidence that health promoting behaviors of the clinical nurses are closely related to depression, familial support, and job satisfaction. This results can be used to develop health promoting program for clinical staff nurses.