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Background: Recently, Medical Act was amended to encourage the induction of combined treatment between Oriental Medicine doctors and Western doctors. As yet, the information infra for combined treatment has not been studied. Objective: This study aimed to design the architecture of information system for combined treatment of the Oriental and the Western Medicine. Method: First we defined the information of combined treatment through the analysis of research trends from the inside and outside of the country. Because the data compatibility is very important, the definition of information must be ahead of anything else. Second, we designed the architecture of information system based on the prior definition. Results: We classified the information for combined treatment by subject such as law, clinic, research, manpower, facilities, and education. In this paper information system examined in three aspects. First the infra layer is organized as hardware, netware, and security. Second is data warehouse layer for the storing, filtering, and extraction of data. Third is service layer which is related to data transmission. And Finally all information for combined treatment is provided through the portal system for medical consumer, political planner, and R&D researcher. Conclusion: In this paper we studied the essential factors of combined treatment information in the view point of information system. But the detailed design and implementation of information system must be followed to effect this results.