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Objectives : This study is designed to evaluate the effect of Hasuogamibang(HGB) on hyperlipidemia and antioxidant activity Methods : For this study, we divide to four groups rat(normal WKY group, normal SHR group, High cholesterol diet and saline treated SHR group, High cholesterol diet and HGB treated SHR group), and observed the change of body weight, weight of liver, cholesterol, triglyceride, glucose, albumin, histologic change of liver and aorta, lipid peroxidation and antioxidant activity of liver tissue, cholesterol gene revelation control efficiency. Results : Total-cholesterol, LDL-cholesterol, Triglyceride were decreased significantly by HGB. But, HDL-cholesterol was increasd significantly. The tissue of liver and aorta were controled defect by HGB on histologic study. Lipid peroxidation and SOD of liver tissue was decreased significantly by HGB. Gene revelation of ACAT and HMG CoA reductase in hepatic tissue was decreased significantly by HGB. Conclusion : This study suggests that HGB is significantly effective on hyperlipidemia and antioxidant activity.