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Purpose : This study is to observe the nephroprotective effects of the traditional prescription, Daebuncheong-eum (DBCE). The DBCE has been generally used for treating various renal diseases, including renal failure. Methods : At first three different dosages of DBCE extract were orally administered once a day for 28 days. At 23th day after DBCE extract treatment, cisplatin has been treated. And then, 5 days after cisplatin treatment. all the rats (6 groups, each of 8 rats per group) were checked in the present study. The changes on the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg in which the effects on cisplatin-induced acute renal failures were already confirmed. Results : Cisplatin induced ARF are induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of DBCE extracts. Conclusion : This study suggest that DBCE extracts showed favorable effects on the cisplatin-induced rat ARF.