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Object : In the present study, we investigated the obesity and blood parameters between Qi-definency and Fire/Heat pattern identification/syndrome differentiation (PI/SD) in acute stroke patients. Materials and Methods : A total of 391 stroke patients within 7 days after onset were consecutively recruited from 12 hospitals across South Korea during Nov. 1st, 2006 to Jun. 31th, 2009. They were diagnosed as Fire/Heat or Qi-deficiency among five PI/SD subtypes by two independent stroke experts. We investigated the differences of obesity and blood characteristics between Fire/Heat and Qi-deficiency by statistical analyses. Results : In male subjects, obesity was significantly associated with Fire/Heat PI/SD. The averaged mean of BMI(24.13kg/㎡) and waist circumference(89.34cm) of Fire/Heat group were higher than those of Qi-deficiency group(22.60kg/㎡ and 83.43 cm, respectively). The number of obese patients was larger in the Fire/Heat group than Qi-deficiency group (p=0.001). Hyperlipidemia was also related with Fire/Heat. However, obesity was not associated with PI/SD in female subjects and the number of hyperlipidemic patients was higher in Qi-deficiency group. Among blood parameters, the levels of triglyceride and fasting blood sugar were higher in the Fire/Heat group compared with the Qi-deficiency group in male subjects. However, total cholesterol of Qi-deficiency was higher than Fire/Heat group in female subjects. Conclusion : In this study, we study showed that obesity and hyperlipidemia are significantly difference between Qi-deficiency and Fire/Heat. We suggest that PI/SD may be associated with clinical characteristics and large population study between PI/SD and clinical characteristics including blood parameters are needed.