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The aim of the present study was to investigate whether Bovine Spongiform Encephalopathy (BSE) is present in this country and to analyze the Global BSE Risk (GBR) status in Bangladesh. A total of 2,000brain samples were collected from cattle older than 30 months of age, slaughtered for human consumption in the district slaughter houses from 2005 to 2006. The brainstem (obex), Pyriform lobe, cerebrum and cerebellum were subjected to histopathological study. Samples that showed some nonspecific lesions were subjected for immunohistochemistry and only brain stem for ELISA for the detection of abnormal prion protein PrPsc. In passive surveillance, annual overall diseases of cattle, buffalo, sheep and goats in Bangladesh were collected from Department of Livestock Services (DLS), Dhaka to investigate the occurrences of neurological diseases. Import related data were collected from “National Export Promotion Bureau”Kawran Bazar, Bangladesh Bank and DLS to analyze the importing products of animal origin (cattle, buffalo, sheep and goats) from different countries to find whether or not the imported products posed any risk for the BSE. In slaughter housesurveillance, histopathologically BSE specific lesions were not detected in any of the brain samples, but other nonspecific lesions were recorded. No PrPsc was detected by immunohistochemistry and ELISA. DLS report indicated absence of BSE in cattle and buffalo and scrapiein sheep and goats. It was clearly observed that Bangladesh imported livestockproducts from countries having GBR level I and II but not from countries having GBR level III and IV. From this study it isapparently seems that BSE is not present in the indigenous cattle in Bangladesh and poses no or negligible risk.