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The lifespan of osteoclasts is critically regulated by varIous cytokines and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This review will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advance in this field with an emphasis on the role of intracell띠ar signaling pathways.


The lifespan of osteoclasts is critically regulated by varIous cytokines and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This review will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advance in this field with an emphasis on the role of intracell띠ar signaling pathways.