초록 close

The purpose of this study is to investigate normal hepatobiliary functions in healthy miniature pigs. 99mTcDISIDA hepatobiliary scintigraphy (HBS) was used for it. Five mCi dose of 99mTc-DISIDA was injected intravenously into 3 healthy adult miniature pigs, and dynamic images were obtained during 1 hour. 99mTc-DISIDA HBS in a miniature pig was evaluated for 6 variables. A cardiac washout occurred within 1 min in all miniature pigs, and radioactivities in the gallbladder were not detected in two miniature pigs. Thus, the initial radioactivity and Tmax of the gallbladder were non-available to identify. Mean Tmax of liver was 8.67 ± 2.08 min and initial small intestinal radioactivity was seen at 9.67 ± 2.52 min after 99mTc-DISIDA injection. Mean hepatic washout time was not detected in 60 min dynamic images. Therefore, 99mTc-DISIDA HBS is the effective diagnostic method to evaluate the function of hepatocyte and bile flow rate. However, it was not a proper method to evaluate the function of gallbladder, which indicates that an additional study is needed to further specify the reasons for the absence of radioactivities in gallbladder of two miniature pigs