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A new method for competent extraction of safflower (Carthamus tinctorius Linnaeus) colorants by using ultrasonicdevice was developed. When comparing to general extraction method, the ultrasonic method showed high extractionefficiency of safflower pigments. Ultrasonic method gave a higher extraction yield of red and yellow safflowerpigments than using general method. It is supposed that the extraction efficiency is to be attributed to high vibrationenergies from ultrasound and finally induced physical changes of the pigments. Furthermore, this study explored theeffects of ultrasonic treatment into the extracted safflower pigments on dyeing of cotton fabrics. Ultrasonic treatmentinto the extracted pigments exhibited significantly improved dyeing properties for the cotton fabrics.