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The purpose of this tudy was to estimate predictivemarkers of intrinsic radiosensitivity in individualswho were xposed to occupational or environmentalradiation. Throughout this proces, the actual biohazardrisks and base-line chromosome damage were valuatedin human population. Further studies were carriedout o provide vidence for the xistence of individualvariations in age-dependent responses throughmicronuclei (MN) assay.Spontaneous frequencies not only vary greatlybetwen individuals, but also working or living areas.It was hown that the increased level of spontaneouscell with MN was observed with increasing age. Therelationship betwen radiosensitivity and the increasedspontaneous level of MN may be in an inverseproportion. Ionizing radiation may be targeted mutagenicefects at he usual exposures of background levelsthat populations were xposed. Age and gender arethe most important demographic variables in determiningwere greater than those in males. The main life-stylefactors influencing the MN index in subjects werecorelated significantly and positively with smoke.The results showed that an indicator of the geneticdamaged rate in MN index in human populationssignificantly corelated with age, sex and life-stylefactors. So far, it is evident hat with regard to theapplication of MN assay al future studies have totake into account the influence of age, gender, andlife-style.In Conclusion, using micronuclei assay technique ailustrated that he MN asay may provide a high*Corresponding author: Laboratory of radiation effect, Korea CancerCenter Hospital, Gongneung-Dong 215-4, Nowon-Ku, Seoul 139-240,Korea.Tel : +82-2-970-1349, Fax : +82-2-977-0381E-mail : thkim@kcch.re.krpotential to ensure apropriate quality control andstandard ocumentation protocol that can be used tomonitor a large population exposed to radiationepidemiologicaly.