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We previously showed that flavanols and their related oligomers (FLO) isolated from cocoacan have immunomodulatory effects on production of the cytokines interleukin-1 b (IL-1b),IL-2, and IL-4. In the present study, we examined whether selected FLO fractions isolatedfrom coa (monomer through decamer) modulate IL-5 protein secretion from resting andphytohemagglutin in (PHA)-stimulated peripheral blood mononuclear cells (PBMC). Al-though FLO fractions were unstimulatory for IL-5 secretion in resting cells, PHA-induced IL-5 release from PBMC was markedly affected by certain FLO fractions. The monomeric andsmall oligomeric (dimer and trimer) fractions enhanced PHA stimulation by 50%, 54%, and43%, respectively. In contrast, the larger oligomeric fractions (hexamer through decamer) in-hibited IL-5 release in the range of 18% to 39%; the tetramer and pentamer showed interme-diate effects. The increment in IL-5 suggests that FLO may preferentially stimulate im-munoglobulin A. We suggest that in the oral cavity this could result in reduction in the riskfor dental caries and periodontal disease. This work offers additional data for considerationof the health benefits of dietary FLO from a variety of foods, including those benefits asso-ciated specifically with consumption of some cocoas and chocolates.17