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A novel kind of composite hydrogel lled with inclusion complexes (ICs) made fromb-cyclodextrins (b-CDs) with amine-terminatedpoly(propylene glycol) (PPG-BA) was prepared by copolymerization of methacryloyl end-capped poly(L-lactide)-poly(ethylene glycol)-poly-(L-lactide) macromer (DMPEGL) with acrylic acid (AA) in water under UV irradiation. Owing to the hydrogen bonding interactionof COOH in AA on the network backbones with NH2 and OH in ICs embedded in the crosslinked network, the composite hydrogelsmechanical properties being signicantly improved. The mass loss test conducted in water indicates that they degrade by following a dualdegradation mechanism, that is, not onlyb-CDs slipping from the polymer axles and then escaping out of the hydrogel network, but alsothe bulk hydrogel network hydrolyzing itself to lose the weight. These composite hydrogels show potential to be used as biomaterials fortissue engineering scaolds and carriers of drugs with controlled release.