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Background and Objectives:the prognosis showing that chronic sinusitis patients with asthma is poorer than those without asthma. But, there are only a few reports about histopathology of chronic sinusitis with asthma and correlation betwen prognosis. The aim of this study is to investigate histopathology of chronic sinusitis and relevance of prognosis after surgery. Materials and Method:A retrospective review of medical records was carried out on 83 chronic sinusitis patients who had undergone endoscopic sinus surgery from grups with good and poor outcomes. Results:The study revealed no statistical diferences on the presence of allergy, OMC CT. However, the poor outcome group showed significant lymphocytes and eosinophils infiltrations with univariant analysis, whereas asthma was proved to be statisticaly different with multivariant analysis. Conclusion:The more lymphocytes and eosinophils infiltrate the mucosa, the poorer the prognosis after endoscopic sinus surgery in the chronic sinusitis patients get. We asume that there will be a good prognostic factor after surgery, and that adequate management and careful follow-up should be taken of patients showing such histopathologic findings. (Korean J Otolaryngol 2003 ;46 :742-6)