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Background and Objectives:Protein kinase plays an important role in transmembrane signalling, which is modulated by cellular transduction by second messengers such as inositol- 1,4,5- triphosphate (IP3), Diacylglycerol (DG), cAMP, to expres biological activity by stimulation of hormones, neurotransmitters, antigens, growth factors. Protein kinase Cs participate in signal transduction of cell, secretion of neurotransmitter, regulation of ion conduction, exocytosis, gene expresion and cellular proliferation. Also, it raises slow motility by Na+- H+ exchange (NHE) and Ca2+ channel in the outer hair cells. It may also be involved in mechanical transduction, cellular proliferation and reproduction in supporting cells, and in producing endolymphs using the KCNE1 and Na+/K+- ATPase in the lateral wall of cochlea. Materials and method:We investigated the imuno-reactivities of the PKC (α,β,γ,δ) via paraffin section and surface preparation of the cochlea of albino guinea pigs. Results:PKCαimmunoreactivities were shown in the outer and inner hair cell cytoplasm andδwas revealed in the type Ⅱ fibrocytes and suprastrial cells in the basal turn of the spiral ligament. Butβ,γwere not shown. Conclusion:We suggest that PKCαmay induce the slow motility and depolarization to mediate the ion conductance in the hair cells. Also, PKCδmay participate in the production of endolymph. We thus conclude that PKCαandδplay an important role in the cochlear signal transduction. (Korean J Otolaryngol 2003 ;46 :733-6)


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