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In order to explore the effect of a regular exercise program on Cobb's angle and fitness variables in teenagers with scoliosis, five high school students (two boys and three girls) participated in this study. They were tested three times; before, during and after the participation of the program, for body fat, lumbar strength, curve angle, and fitness variables. 1. During the measured time frame, body fat content has been reduced in a favorable direction, and it was statistically different (P<.01). 2. Lumbar strength was increased throughout the measured time frame and was statistically different (P<.05) Also, lumbar strength in diverse angles were increased but it was not statistically significant after post-hoc test (P>.05). 3. Evaluations of Cobb's angle of thoracic region was changed after the program and it was statistically different (P<05). But no difference was found in the lumber region (P>.05). 4. In physical fitness variables, muscular strength, sit-and-reach, and balance stability were not changed. However, trunk backward extension and sit-ups were increased after the program (P<.05). In conclusion, regular weight training, ball-exercise, and dumbbell exercises provided a positive effect on Cobb's angle and lumbar strength in patients with scoliosis. It appears that the use of combined exercise programs including weight training, ball exercise, and dumbbell exercises are recommendable for patients with scoliosis. And its application should be regular and systematic.