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The purpose of this study was to analyze the effect of resistance exercise prescription on body composition, abdominal fat and metabolism regulatory hormone function in the severe obesity middle-aged women.Eight severe obesity middle-aged women were selected to perform the resistance exercise prescription with in 60~70%RM, for 60min/day, 3~4times/week during 12weeks.The statistical techniques utilized in the study were paired t test and regression analysis. The .05 level was initially established in significance.The conclusions of the study were as follows;In the body composition, abdominal fat function there were significant difference on the body weight, total body fat, percentage of fat, body mass index, total abdominal fat, visceral fat volume, subcutaneous fat volume, and visceral-to-subcutaneous fat volume ratio were significantly decreased. In the metabolism regulatory hormone function there were significant difference on the leptin and Free Fatty acid were significantly increased, insulin and cortisol were significantly decreased.