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The effect of treatment with pine needle oil upon rat hepatocytes exposed to alcohol was investigated. The bodyweight gain, ratio of liver and kidney to body weight, and serum biochemistry of rats administered both alcohol and pineneedle oil were compared to control rats treated with alcohol alone. Normal untreated control rats, negative control rats withethanol treatment, positive control rats with both alcohol and the commercially available hangover cure solution (HCS)treatment and the test group with both alcohol and pine needle oil treatment exhibited aspartate aminotransferase (AST) levelsof 84.43±47.88 U/L, 254.57±463.20 U/L, 70.29±12.60 U/L and 67.00±5.06 U/L, respectively, and cholesterol levels of 95.71±6.86 mg/dl, 113.80±38.19 mg/dl, 91.57±6.30 mg/dl and 82.29±4.98 mg/dl, respectively. Alanine aminotransferase (ALT)levels were 44.00±9.04 U/L in normal untreated control rats, increased to 215.43±428.93 U/L with the administration ofethanol, but interestingly were significantly reduced to 37.83±6.57 U/L in the test group (p<0.05). Triglyceride (TG) levelswere 39.57±8.62 mg/dl in normal untreated rats, increased to 73.71±61.20 mg/dl in rats administered alcohol, but werereduced to 26.14±4.82 mg/dl in the test group (p<0.01). The pine needle oil treatment significantly reduced the levels of AST,ALT and TG compared to the control rats. These results indicate that pine needle oil can positively mediate the effects ofalcohol on hepatocytes and general liver functions.