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Waxy brown rice fermented with Coprinus cinereus was extracted with methanol. The rats were fed the diets,contaning the freeze dried extract at the rate of 0.5, 1.0, and 2.0 g/day/body weight for 14 days. Rats treated with carbontetrachloride to induce hepatotoxicity. After sacrificing the rats, the enzyme activities of aspartate aminotransferase (AST),alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GTP) in serum were determined. Serum biochemical analyses for albumin, total protein, triglyceride and both total and HDLcholesterolwere carried out, along with histopathological study of liver tissues. These results suggested that waxy brown ricecultured with C. cinereus could exert a hepatoprotective activity against the hepatotoxicity caused by chemicals such as carbontetrachloride.