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This experiments was designed to observe the effect of period and dose of ingestion of grapes on renal failure in dog. After the dogs had been mixed of general feed, raisins from U.S.A and fresh grapes from Chile selling in Korea. We observed the clinical sign, and analyzed the blood and urine using by biochemical test. The experiment was executed by the two following groups. The experiment group 1. derived renal failure by supplying the mixed general feed with fresh grapes and dry grapes 15g per weight kg, 2 times a day (AM 09, PM 21), the experiment group 2. executed to derive renal failure by supplying the mixed general feed with fresh grapes and dry grapes 40g per weight kg, 2 times a day.Extraction of blood for analysis was conducted one time a day and clinical test for renal failure was executed by means of a blood analysis, biochemical analysis, urine analysis, excretory urography (E.U) and E.R.D-screenTM urine test (Heska, USA). The results of group 1 were normal ranges (BUN 9.0~22.6mg/dl, creatinine 0.8~1.2mg/dl, Ca 9.7~12.3mg/dl, Pi 2.9~4.6mg/dl), renal failure was not observed. On the 3rd day in group 2, azotemia was arisen from the increasing BUN 83mg/dl (7~25 mg/dl), creatinine 2.3 mg/dl (0.5~1.4mg/dl), when executed urine was tested by E.R.D-screenTM test using in the early kidney disease diagnosis, microalbumine state was high positive, and it showed stale delay by using excretory urography (EU).This study demonstrated that acute renal failure by grapes and raisins dependent on food dose, and specific characters of individual.