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To compare the sedative effects using intermittent intravenous bolus injection with tiletamine-zolazepam (n = 5, TZ group), xylazine-ketamine (n = 5, XK group) and propofol (n = 5, PI group), we investigated the changes of hemodynamic (heart rate, arterial pressure), SpO2 , rectal temperature, respiratory rate and pain score during 60 minute sedation and 40 minute recovery period in beagle dogs. The value of rectal temperature was significantly higher in PI groups (p < 0.05) during recovery period. The value of heart rate was significantly lower in XK group (p < 0.05) during sedation. The changes of respiratory rate were similar tendency in all groups. The change of SpO2 was stable during sedation and value was significantly higher in PI group (p < 0.05) during recovery period. The value of systolic arterial pressure (SAP) was significantly lower in XK group (p < 0.05) than PI group during sedation and recovery period. Low analgesic effect occurred in PI group. We concluded that intravenous anesthesia by intermittent bolus injection with propofol is useful in stabilizing rectal temperature, SpO2 and hemodynamic during sedation and provide fast recovery, but have low analgesic effect.