@article{ART001068088,
author={mihi yang},
title={Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges},
journal={Journal of Cancer Prevention},
issn={2288-3649},
year={2007},
volume={12},
number={2},
pages={75-78}
}

TY - JOUR
AU - mihi yang
TI - Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges
T2 - Journal of Cancer Prevention
JO - Journal of Cancer Prevention
PY - 2007
VL - 12
IS - 2
PB - Korean Society of Cancer Preveniton
SP - 75
EP - 78
SN - 2288-3649
AB - The genetic polymorphism of cytochrome P450 (CYP) 2A6 has been emphasized to induce variations in smoking behavior, and in susceptibility to smoking-related cancer. However, there were a few studies concerning the CYP2A6 polymorphism in Korean populations. Therefore, focusing on presence of the CYP2A6 null allele (CYP2A6*4), I studied distribution of the CYP2A6 polymorphism in a Korean population (n=100) and its effects on sister chromatid exchange (SCE), a responsive biomarker for smoking or carcinogens. As results, the subjects who had the homozygous mutant type, the CYP2A6*4/*4, occupied 5.4% of the all subjects and most of them belonged to nonsmokers. However, the CYP2A6 polymorphism was not associated with the SCE levels (p=0.25), which were related to sex, smoking, and alcohol drinking. Therefore, presence of the CYP2A6 null allele may influence smoking behavior, however, it may be not involved in SCE-medicated cancer process. (Cancer Prev Res 12, 75-78, 2007)
KW - CYP2A6, Genetic polymorphism, Smoking, SCE
DO -
UR -
ER -

mihi yang. 2007, "Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges", Journal of Cancer Prevention, vol.12, no.2 pp.75-78.

mihi yang "Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges" Journal of Cancer Prevention 12.2 pp.75-78 (2007) : 75.

mihi yang. Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges. 2007; 12(2): 75-78.

mihi yang. "Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges" Journal of Cancer Prevention 12, no.2 (2007) : 75-78.

mihi yang. Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges. Journal of Cancer Prevention, 12(2), 75-78.

mihi yang. Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges. Journal of Cancer Prevention. 2007; 12(2) 75-78.

mihi yang. Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges. 2007; 12(2): 75-78.

mihi yang. "Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges" Journal of Cancer Prevention 12, no.2 (2007) : 75-78.