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As an alternative to 2,2-bis[4-(2'-hydroxy-3'-methacryloyloxypropoxy) phenyl]propane (Bis-GMA) that contains Bisphenol A, a possible endocrine disrupter, novel multifunctional methacrylated prepolymers, 80-3MA and 4000-3MA mix (2MA:3MA:4MA mixture=45:45:10 wt%), were synthesized and then dental pit and fissure sealants composed of the novel prepolymers, diluent, and inorganic filler were prepared. The viscosities of the prepolymers were much lower than that of the Bis-GMA control. From the results of 1H-NMR analysis, the chemical structures of the prepolymers were similar to that of Bis-GMA. In addition, the polymerization shrinkage, photoconversion, polymerization depth, and diametral tensile strength of the dental sealants formulated with 80-3MA and 4000-3MA mixture prepolymers exhibited comparable to or better than those of the existing Bis-GMA-based one. These results suggest that the novel 3MA methacrylated prepolymers which have no endocrine disrupter can be an alternative to Bis-GMA and be applicable to biocompatible dental materials.