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Recent advance in genetic engineering and production of the monoclonal antibody(MAb) allows one to generate therapeutic proteins in large amounts. Therapeutic proteins we overview here include interferon, insulin, EPO, colony stimulating factor (CSF), blood factor, therapeutic enzymes, therapeutic hormones, and cytokines (growth factors, interleukins etc.). We focused on the recent progress in research and development of MAb-based therapeutics and analyzed the recent market trend related to the therapeutic proteins.