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Regular exercise is known as an important factor for reducing danger of heart disease, cancer, osteoporosis, diabetes and many other diseases as well as promoting metabolic functions, immune systems, antioxidant defense system. Otherwise, acute bout of strenuous exercise induced injuries, chronic fatigue and many diseases, and it shows that main cause is theory of free radical. In General, increasing antioxidant enzyme by regular exercise could reduce oxidative stress in human body, but if free radical production overwhelms antioxidant defence system in acute bout of strenuous exercise, it induces negative effects. Also, it shows that is controled by the intensityduemethod of exercise and the fitness level of the subject, age, gender. As a result, we suggest that increases intensity of exercise gradually and selects other factors well for improving health by regular exercise. Also, if players who is professional need to attend in acute training long time, they can protect oxidative stress by antioxidant supplementation such as VitC., VitE. and Selenium.